Ehlers *, Ian Gizer, David Gilder, Rachel Yehuda The Scripps Research Institute, La Jolla, Californiaīackground: American Indians appear to experience a higher rate of traumatic events that what has been reported in general population surveys. Keywords: Genotying, mentally ill, tobacco smokingĭisclosure: E. Female schizophrenicOPRM1 *G and patients with DRD2 A2 (GG) alleles smoked more than the others. However, homozygous A2 (GG) allele carriers smoked more than patients with DRD2 AA/AG or GG genotypes.Ĭonclusions: This study indicates sex, DRD2 Taq1A and OPRM1 genotype differences among tobaccosmoking and nonsmoking schizophrenic and bipolar patients. Thepresence of the A1 (A) allele of DRD2 was not associated with greaterprevalence of tobacco smoking. Overall, DRD2 Taq1A genotypedifferences had no effect on the number of cigarettes smoked per day. The schizophrenic OPRM1 *Gcarriers smoked more than the AA alleles (p<0.05). Surprisingly, female schizophrenic patients smoked more cigarettes per day than the males (p< 0.01). Results: Tobacco smoking was more prevalent in male than in female schizophrenics, but equal inbipolar males and females. The Polymerase Chain Reactions (PCR) wereperformed using One Taq 2X Master Mix with standard buffer. Genomic DNA was extracted from whole blood with the GentraPuregene Blood kit (QIAGEN). The number ofcigarettes smoked per day was used to estimate the degree of tobacco smokingreinforcement.
They were classified into three groups: current smoker, formersmoker, and never smoker by tobacco smoking status self reports. Methods: A total of 177 schizophrenic and 110 bipolar patients were recruited andgenotyped. The objectof the present study was to determine the OPRM1 A118G (rs1799971), dopamine D2receptor (DRD2) Taq1A (rs1800497) genotype, and sex differences of schizophrenicand bipolar smokers vs nonsmokers.
Domino *, Mika Hirasawa-Fujita, Michael Bly, Vicki Ellingrod, Gregory Dalack University of Michigan, Ann Abor, Michiganīackground: Why the mentally ill smoke tobacco more than normal persons is unknown.
0 kommentar(er)
